Serotonin and dopamine do stuff in other places throughout the body, and it would be unpleasant for all those processes to start going crazy. If you just want it in the brain, it makes more sense to block the reuptake or cause more release of it in the brain
Also, a form of dopamine is used as an oral drug for people with Parkinson’s disease. It’s usually given with a drug that prevents it from turning into dopamine before it gets to the brain so you don’t get those side effects
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