NSAIDs work by inhibiting prostaglandin synthesis. Prostaglandins are proteins that are a key player in the immune system’s inflammatory cascade of events.
However, in certain cells that line the inside of the GI tract, prostaglandins are necessary for production of mucous, which lines the inside of the tract to protect against stomach acid and any other caustic substances. Without a proper mucous lining, the inside of the GI tract, especially the stomach (which manufactures hydrochloric acid to aid food digestion), can sustain substantial damage leading to ulcers, pain, bleeding.
NSAIDs work by inhibiting prostaglandin synthesis. Prostaglandins are proteins that are a key player in the immune system’s inflammatory cascade of events.
However, in certain cells that line the inside of the GI tract, prostaglandins are necessary for production of mucous, which lines the inside of the tract to protect against stomach acid and any other caustic substances. Without a proper mucous lining, the inside of the GI tract, especially the stomach (which manufactures hydrochloric acid to aid food digestion), can sustain substantial damage leading to ulcers, pain, bleeding.
NSAIDs work by inhibiting prostaglandin synthesis. Prostaglandins are proteins that are a key player in the immune system’s inflammatory cascade of events.
However, in certain cells that line the inside of the GI tract, prostaglandins are necessary for production of mucous, which lines the inside of the tract to protect against stomach acid and any other caustic substances. Without a proper mucous lining, the inside of the GI tract, especially the stomach (which manufactures hydrochloric acid to aid food digestion), can sustain substantial damage leading to ulcers, pain, bleeding.
NSAIDs are notorious for causing gastrointestinal ulceration/bleeds. People with diseases such as crohn’s/ulcerative colitis are already at an increased risk for GI bleeding due to the increased levels of inflammation in the gut walls – adding an NSAID into the mix will increase that risk further.
Apparently NSAIDs can also cause acute flares of IBD, though there’s lots of conflicting snd inconclusive evidence.
NSAIDs are notorious for causing gastrointestinal ulceration/bleeds. People with diseases such as crohn’s/ulcerative colitis are already at an increased risk for GI bleeding due to the increased levels of inflammation in the gut walls – adding an NSAID into the mix will increase that risk further.
Apparently NSAIDs can also cause acute flares of IBD, though there’s lots of conflicting snd inconclusive evidence.
NSAIDs are notorious for causing gastrointestinal ulceration/bleeds. People with diseases such as crohn’s/ulcerative colitis are already at an increased risk for GI bleeding due to the increased levels of inflammation in the gut walls – adding an NSAID into the mix will increase that risk further.
Apparently NSAIDs can also cause acute flares of IBD, though there’s lots of conflicting snd inconclusive evidence.
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