2 main reasons that I can think of
1. Cost: A quick google search says SpaceX can send a payload to the ISS for about $2700 per kg (~$1240 per lb) so getting it on a one way trip is going to be even more expensive since you can’t reuse anything and you’re sending it a lot farther.
2. Safety: If you spill a barrel something off the back of a truck, there will be a lot of work to clean it up and protect the environment/water/air but it can be managed on a local/regional basis. Now picture if there was a Challenger Shuttle type disaster, now thousands of pounds of toxic waste is widely distributed in the atmosphere and is a global catastrophe. i.e compare the distribution of spilling 1/4 teaspoon of water vs a huge vape cloud
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