If it blocks adenosine, why can’t it block it forever? What process stops it from working over and over?
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You can’t stay awake indefinitely because sleep is necessary for your brain to function properly. The longer you stay up past what is considered healthy, the further you go into what is considered sleep deprivation psychosis.
Basically, your brain is still getting sleepy after awhile as a safety feature. It is possible for more powerful substances than coffee to keep you up for several weeks, but there is no way around that inducing psychosis and inevitably killing you if you tried to push your brain too far past its limits
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