When I try to google it I only get the information that its just bad for your health, but how exactly does it work that you can’t mix ibuprofen with alcohol? If someone could explain it in a way that makes sense that would be great, thank you
In: Chemistry
I’m just a medical student, so don’t take this as medical advice.
Ibuprofen inhibits cyclooxygenase, which has two forms (COX-1 and COX-2).
COX-2 stimulates the synthesis of prostaglandins that cause inflammation.
COX-1, however, stimulates the production of prostaglandins that protect the stomach and intestines.
The inhibition of COX-1 means the stomach and intestines are more susceptible to damage, and alcohol causes inflammation and erosion in the stomach and intestines.
So together they increase the risk of peptic ulcers, which in addition to bleeding increase the risk of stomach cancer.
There are also effects on the liver, kidneys and heart, but AFAIK the big sticking point for ibuprofen is the stomach and intestines.
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