1. Updates may change the core operating system files. Having your computer using/accessing them while updating can lead to corruption.
2. Programs are often not perfect and have memory leaks, if programs are not restarted every so often, they can end up consuming too much ram and crashing.
3. Servers often use ECC (Error check control) memory. This checks for any corruption in memory and automatically corrects it. Desktops do not do this as a random memory error may only happen once every few days, a minor enough issue not to worry about for a single user, but for a server that needs to be up for months at a time, this is a significant concern.
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