. Why do auto immune diseases like psoriasis only target certain parts of the body or skin and not everything?
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To answer your question, autoimmunity is caused by antigen-specific immune cells attacking specific cell types. Each of these immune cells are tailored to recognize a certain pattern of molecule, and can only bind and attack cells that display that pattern. This is why rheumatoid frequently targets cartilage, MS targets myelin, and type 1 diabetes targets pancreatic islet cells (insulin producing cells).
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