An actual safety issue would be the amount of money in the drawers making a robbery more attractive. This is why convenience store and gas stations constantly remove cash from the drawers. Accepting 50 and 100 bills means having to keep more money in the drawer.
Everyone so far has said because of counterfeit, but that isn’t it. 100s and 50s are the most counterfeited *outside* the US. Inside, it’s the $20 bill that’s most counterfeited. Think about it; why would you counterfeit bills no one would take?
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