TL;DR Using certain substances means your own body will stop producing those substances on its own. Withdrawal is caused when your body does not have enough of whatever substance it has become accustomed to.
[I like this explanation from a a post a year ago.](https://www.reddit.com/r/explainlikeimfive/comments/k9mp5p/eli5_why_does_your_body_go_into_withdrawal_when/gf57vtw/)
> Your body always wants to reach a “balanced” state known as an equilibrium. If you regularly use a substance that provides additional chemicals or signals (stimulants), your body will respond by producing less of those to balance it out. Likewise, for substances that block chemicals or signals (depressants), your body will try making more of them.
>Withdrawal happens when you stop supplying the substance. Now your body is either greatly lacking or greatly producing certain chemicals or signals, causing a series of other uncomfortable to fatal symptoms. The easiest way to reach your previous “balance” and stop withdrawal symptoms is to continue taking the substance, making these physical additions difficult to overcome.
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