Why do people claim ketamine will have long lasting or permanent impact on your mental health, but other NMDAR-antagonists don’t?

Question

If I take dextromethorphan (NyQuil) then four or so hours later I’m back to feeling like I did before I took it.

Just to be clear, I’m asking about taking ketamine under the supervision of a doctor. Not recreationally.

In: 23

Answer 1

The proposed effect is not unique to ketamine at all? Other nmda antagonists including pcp and dxm have been examined, ketamine just seems to have a preferable safety, tolerability and efficacy profile