I am asking mainly to know about stimulants for ADHD, so dopamine and norepinephrine reuptake inhibitors, but happy to hear about SSRIs too if it’s the same.
Why does taking dexamphetamine, for example, result in more and more exhaustion if taken for days in a row? Is it because the purpose of reuptake is to recycle the chemical, so inhibiting that means you don’t have enough the next day and can’t produce it quickly enough so you’re always at a deficit or something? I’ve tried searching google and this sub but I have no biology or chemistry background at all so I never understand the answers. Please, ELI5!
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The transmitter chemicals are in the space between the cells, which allow the cells to interact. The chemicals are taken back in by reuptake proteins on the cell membrane to be used again. The reuptake inhibitor drug plugs the proteins so it doesn’t happen as often, and the amount in the space between the cells is kept higher which promotes the interaction. Why one feels depleted I don’t know. Maybe the extra activity in the brain is tiring.
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