What does it mean?
In: Chemistry
“ mab” for monoclonal antibody, the “u” indicates the antibodies are humanized which has to do with the type of cells used to produce the antibodies. Early mabs were produced from chimeric cells composed partially of mouse cells. The technology has advanced to using wholly human cells.
mab stands for antibody. there are different variations based on the species it’s based on. below is a general list that explains this further:
1. Mouse-derived antibodies: The suffix “-omab” indicates a mouse-derived monoclonal antibody (mAb).
2. Chimeric antibodies: The suffix “-ximab” indicates a chimeric mAb.
3. Humanized antibodies: The suffix “-zumab” indicates a humanized mAb.
4. Human-derived antibodies: The suffix “-umab” indicates a human-derived mAb.
5. Partly chimeric and partly humanized antibodies: The suffix “-xizu-” indicates partly chimeric and partly humanized antibodies.
6. Pure human antibodies: The suffix “-u-” indicates pure human antibodies.
7. Human antibodies targeting the immune system: The suffix “-lumab” indicates human antibodies targeting the immune system
Those aren’t drugs they are antibodies made against various targets. The convention is to use mab or something like it based on whether the antibodies are based on mouse or human or other animals
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