Consistency in combustion with regards to tuning. Multiple fuels can be run but in varying volumes, such as e85 vs 93 octane, race fuel etc, but they all need specific tunes and sometimes larger fuel delivery lines/pumps for the quantities required
As an edit, other things can also be an issue for uncommon fuels that may not be stored the same as standard gasoline, or are corrosive to delivery or internal engine parts, things like that which make them unusable for internal combustion engines
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