If your stomach is pretty much empty the digestive juices in it can be concentrated. the pill hits the pool and dissolves quickly! In the case of vitamins it can cause your body to reject it and you barf. If it’s a medication, some of them need to be absorbed slowly and if you absorb it quickly it can shock you system. having food in your stomach dilutes the stomach juices and slows absorption.
A lot of medication is particularly hard on the stomach.
NSAIDs (Non-Steroidal Anti Inflammatory Drugs) like Advil for example temporarily disable your stomachs ability to produce mucus that protects the stomach lining. So extended use of Advil for some people can cause ulcers as the stomach acid burns away at the stomach lining.
Eating with food reduces this effect.
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