The brain has a lot of specific functions that can go wrong or work better or worse in different people, or just work differently.
Just like the ability to recognize faces and interpret facial expressions is one such function, telling left from right is another.
Usually this is related to differences in, or damage to, the parietal lobe of the brain (and typically on the left side), a part of the brain where damage is often associated with inability to understand or perform the shape and form and structure of things. Everything from recognizing specific patterns or associations, to the understanding of language, letters or math.
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