I have always wondered why when some people drink coffee or smoke a cigarette, they almost immediately feel the urge to poo.
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Several compounds have several reasons.
For instance caffeine kinda spurs on your bloodlfow to the kidneys so your body produces urine faster…or just generally fuels the need to go to the bathroom.
Since your liver and kidney kinda disarms and unpacks stuff coming in… it is accelerating that part of the equation.
That is how most things we consider diuretic act in one way or another…there is ultimately many interactions and reasons.
Adhd meds such as adderall and ritalin for instance make you go to the toilet way more often too for similar reasons… it usually tends to be stimulating compounds that do this.
Generally you have some process which either accelerates something or spurs something on to be more likely to be ejected out…for instance on a ketogenic diet you will need to pee more often initially because your body cannot handle that many ketones suddenly as it isn’t used to it yet so your body ejects the rest….eventually it normalises though.
It is also what many bodybuilders concerns are.. you dont have low testosterone because your urine test sais it’s low… it is just the excess your body no longer needs to throw out.. it has its balance now…so you gotta pee less too.
For nicotine specifically, it binds and activates specific acetylcholine receptors (nicotinic).
These trigger the pre-synaptic autonomic nervous system, both sympathetic and parasympathetic. It’s the parasympathetic system that will trigger defecation impulse.
These receptors are also found at the neuromuscular junction, so twitchiness can result at low doses. At high doses, muscle spasms and respiratory issues can lead to death.
Doesn’t take much: a drop absorbed through the skin can be fatal.
It’s been 35 years since I memorized this shite, I might be mistaken here and there.
They are amphetamines and so make your heart rate blood pressure respiration body temp and CNS in general go up and part of that is your digestive system as they’re wired together in a way that is known as parasympathetic. Same reason that CNS depressants like opioids will bind you up terribly. Now, why alcohol makes you poo the next day, that’s a mystery to me as it is a depressant. Maybe because the system wants it purged?
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