Your brain works by moving salt ions through the cell walls of its neurons. Your muscles work in a similar way.
Sometimes, your body gets a little extra salty near one of your nerves (bundles of neurons that carry neural signals between your brain and the rest of your body). That extra salt makes the nerve think that the brain is trying to send a signal (because from the nerve’s perspective that’s basically impossible to differentiate), so it sends a signal down to the nerve’s end.
If that nerve happens to be connected to a muscle, then that muscle will twitch. But because the section that started the impulse was only a little extra salty and likely did not hit all neurons in the bundle at the same time, it only makes the muscle twitch a little instead of a big, full muscle flex.
([here’s the /r/askscience version](https://www.reddit.com/r/askscience/comments/2yeqfr/when_muscles_twitch_uncontrollably_very_slightly/))
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