I know the rules say “don’t literally explain it as if it’s a 5-year-old” but in this case I truly think the “dumbest” you can make the answer, the better
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It’s the square-cube law. If you make a creature 10 times bigger it weighs 1000 times more (because its length, breadth and height all scale up). At the same time it gets 100 times stronger because strength scales with the cross section of bones and muscles. So the strength-to-weight ratio is now 10 times less and just standing up is now difficult and dangerous, and running is impossible.
So you can’t just scale up creatures and have them work the same. The square-cube law bites in many other ways like breathing, eating, staying cool, etc. That’s why elephants are so stockily built compared to smaller creatures. It also means that real giant humans like those in *Game of Thrones* and also tiny humans like those in *Ant Man* are completely impossible.
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