Your stomach has 2 sphincters: the oesophageal sphincter (which connects the oesophagus and the stomach) and the pyloric sphincter (which connects the stomach to your small intestine)
When you are in a state of fasting, your oesophageal sphincter is closed to keep from having acid reflux and your pyloric sphincter is open (well more relaxed).
When you eat something it stimulates you stomach. Which means it relaxes the oesophageal sphincter and closes off the pyloric sphincter. Which will give the medicine dissolve in the gastric acid. And it will pass slower to the small intestine where it will be absorbed.
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