With a few exceptions (like NSAIDs) often patients are told to take with food for psychological reasons. If it’s SO POWERFUL it will burn your stomach out then it must be strong stuff and bound to work better then namby pamby paracetamol.
Source: working in A&E. Especially for our “regular” patients, giving complicated instructions on how to take a medicine (whilst remaining within BNF dosing guidance) greatly increases the effectiveness any meds they are given. Having to take with food or it being very important that meds are taken at exact times are commonly used.
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