There are a lot of factors as to why you might need to take a medication with food, and there are even some foods and drinks that may be contraindicated. For instance some medications are not recommended with grapefruit juice because it blocks an enzyme in the small bowel that is responsible for digesting the medication and as a result, more of the medication will wind up in your bloodstream doing potential damage to your liver. Somewhat counterintuitively it can also block certain transporters responsible for circulating the drug in your body, thus reducing the dosage and effectiveness.
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