We do; Voyager-1 and -2 for example are powered by [Radioisotope thermometric generators.](https://en.wikipedia.org/wiki/Radioisotope_thermoelectric_generator#Space) This type of nuclear power source harnesses the energy of decaying radioactive atomic nuclei by converting the heat generated directly to electricity. They don’t use fission like land-based nuclear power plants because a fission reactor is very big and heavy and would be hard to get into orbit.
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