You smoke weed, but snort coke.
What would happen if I snort weed (hypothetically, if even possible) and inhale coke(like the powder)?
In: 1
So the real answer lies in solubility.
Recreational cocaine and methamphetamine are manufactured as hydrochloride salts which makes them quickly dissolve in water. Morphine diamorphine (heroin) are water-soluble compounds isolated from raw opium.
Upon contact with moist mucous membranes, water-soluble drugs dissolve and pass into the bloodstream; the finer the powder, the faster it dissolves. Blood vessels that supply mucous membranes in the nasal cavity are very close to the skin surface which speeds absorption and onset of the drug’s effects. However, water-soluble drugs will pass across any mucous membrane.
Powdered opiates dissolve more slowly than hydrochloride salts. Incorrect opiate dosing can be fatal. Dosage control and the speed of onset make injection preferable to insufflation.
THC has very low solubility in water. Even high-THC forms of dried cannabis flower contain considerably more inert plant material than drug. Therefore, insufflation is ineffective.
When heated, THC becomes an aerosol with particles small enough to diffuse into the bloodstream through the lungs. Burning cannabis flower and oil actually destroys THC. It is more efficient to consume cannabis by heating it to a point just short of pyrolysis.
Like THC, the other drugs mentioned above can be heated and inhaled, which greatly speeds their absorption.
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