Your hand has to wrap around the grip of a mag loading pistol. That means the bullets cannot be larger than what you could wrap your hand around. A revolver can have larger ammunition without affecting the grip width. Also, I think if a chamber jams, you can cycle to the next one, whereas when a mag loader jams, you have to unjam it before you can discharge it, but I don’t know how significant that is with modern day firearms.
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