In order to detonate a cartridge you need to impact the primer on the bottom of the cartridge with enough force to deform it enough that it detonates. This is very dificult to do unless you load it into a gun that is designed to do exactly this. Of course there are conditions in which cartridges can detonate so you need to handle it like any other explosive. But there is no need to handle it much more carefully then that as the cartridge itself can handle a lot of abuse without detonating.
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