Nuclear weapons work through nuclear fission. While a majority of elements can undergo nuclear fission, some are able to do so more easily than others, requiring less work. Scientists decided that Uranium-235 and Plutonium-239 were the best options as they are able to achieve nuclear fission very easily. It is possible to make nuclear weapons with the isotopes of other elements, but none are as easy, and possibly as cheap, as using uranium and plutonium.
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