From what I remember from high school, it’s not the nucleus but the outer electron shells which define chemical properties.
Chemical bonding capabilities are depending on the willingness to accept a shared electron or the ability to lent a shared electron, in salts like Na+ and Cl-. The breaking of chemical bonds, like creating H2 and O2 from water, are also happening in the electron shells.
The more to the right of the period table, the fuller the outer electron shells and the harder to make it react with something.
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