Sparing the details, a colleague of mine recently had his big toe amputated due to diabetes. I wondered why being diabetic could lead to this as it’s common.
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High blood sugar disrupts vascular integrity, among MANY other severely detrimental effects.
High blood sugar also partially explains the cholesterol clogs your arteries hypothesis.
The reason we find clumps of cholesterol in arteries is probably an attempt at the body from repairing damage caused by hyperglycemia.
The main reason for this is that 80%+ of cholesterol is synthethized in your liver, not absorbed from food. If you have high cholesterol, it is likely your body’s intent to produce that cholesterol. As a significant component of cell membranes, it becomes clear why it accumulates around vasculature, they are suffering damage and it’s being repaired inneffectively, since hyperglycemia usually continues, and efforts to lower cholesterol are usually started.
An analogy so basic it could come from a caveman: Sort of like trying to duct tape a hole in a bucket, but it’s full of water. You end up using way too much tape and it’s still leaking.
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