The harder you exert yourself, the hotter your cells become. If you are already close to the point where they are finding it difficult to function, your body will prevent you from exerting yourself further in order to avoid overheating. This manifests as a feeling of fatigue.
Dehydration (which can happen from sweating) also makes this happen faster, since sweating is how your body cools itself. If you don’t have a lot of extra water left, your body will make you tired sooner since more cooling is not in the “budget”.
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