I can’t speak for cocaine but the chemicals needed to make drugs are often regulated for that very reason. My dad works for a chemical company and had to fire a guy for stealing some a small amount of some chemical that he took for his paleontology hobby ( he couldnt get it any other way) The problem was the chemical was highly regulated because it was used to make heroin or meth. Thats how the company knew it was missing.
When you can’t get the proper chemicals, you substitute.
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