Why does muscles fail to perform an action after repeating a routine several times (push-up or any exercise with muscles)?
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There are two different ways to tire your muscles out
The first is by depleting their store of oxygen and then of ATP to work with. This is the muscle literally running out of fuel and is why you get tired over time, its worse with high weights
The second is much more common with low weights and its by depleting the neuro transmitters. If you can do 50 lbs curls then a bunch of 5 lbs curls should be no problem from the fuel supply, but each curl fires the neurons which tell the muscles to go and overtime they use up their supply of neurotransmitters and need time to replenish. Lifting a heavier weight will involve more neurons telling more muscle fibers to fire so it’ll tire you out a bit faster on this front too but for heavy weights its generally the fuel above. This second cause is why someone who can do a 300 lbs bench press can’t just do 90 lbs bench presses indefinitely
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