So, there are 2 main ways this prevention of polyspermy happens.
1st, there is a fast reaction by the egg upon sperm entry. It depolarizes the membrane, which prevents other sperm from being able to bind to it. Kinda like a magnet.
2nd, is a slow reaction. It is the hardening of this egg membrane, which is called cortical reaction. This hardening of the membrane makes the egg impenetrable to other sperm.
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