Why does Propofol put you to sleep so quickly?

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I got a procedure done and they used an anesthesia which I believe is called “Propofol”. It put me out so fast, it felt like I got violently dragged into sleep. Immediately after I saw that white liquid being injected in my vein, I passed out.

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Proposal works by interacting with rhe GABA receptors in your brain, that play a key role in the body’s ability to process sensory information, especially chronic pain.

GABA agonists like propofol produce the effects of high GABA levels, which generally makes information processing more challenging. The result is memory loss and generally reduced cognitive function.

Simultaneously, it is metabolized by something g known ad the endocannabanoid system, which produces a metabolite called AEA that interacts with cannabanoid recpetor 1. This is a brain wide process, and generally inhibits neurotransmitter function. It prevents nerves from communicating efficiently.

The combined result is a brain that can’t really process information or run most brain functions. The brain stem is largely uninterrupted, keeping vital functions working, and most body wide processes are managed hormonally not neurological, so the body continues to function whike most to all concious brain function is impaired.

If not for the GABA activation, propofol may cause vivid hallucenigen effect like most drugs that selectively bind to heteroreceptors like CB1, however GABA impairs memory and sensory function preventing this from occuring.

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