We’d need more info in order to give a specific answer. For instance: What microphone or devices are you using? Are there (sound) speakers? What apps are involved?
Microphones themselves have a pickup pattern and can be made such that sounds emanating from other directions are picked up at a lower volume or not at all.
The audio can be processed in order to eliminate the call audio (or any audio output). This is since you can utilize destructive interference. This can be done for phones to avoid feedback when used in loudspeaker mode.
The audio itself may not be passed on as part of the input. Without external speakers, the sound output of a computer would not be sent as part of the input to the call software as this could cause a feedback loop. Involving speakers would motivate the prior 2 paragraphs.
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