There are two reasons – mint dulls your sense of sweetness (that’s why you can eat mints that are basically made of a sugar cube and mint oil) and also the chemicals used to make the toothpaste frothy heighten your bitterness sense, just as a side effect.
If you take all the sweetness put and double the bitterness, orange juice, or pretty much anything will taste odd and often unpleasant! Orange juice is especially bad as it often contains a lot of the pith and skin from the orange which has a bitter taste, normally masked by the sweetness of the juice.
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