Regardless of the numbing agent (sodium laureate) the sweet flavour of toothpaste is strong and basically overwhelms your taste receptors for sweetness. The receptors go shut down for a while, so you won’t be able to register anything sweet until they recover, but you will still taste all the other aspects of whatever you eat/drink, and whatever it is will be way out of balance without the sweetness.
This effect can be super beneficial when pairing wine with food though!
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