– Why does untreated diabetes cause parts of limbs to die?

Question

– Why does untreated diabetes cause parts of limbs to die?

In: Biology

Answer 1

Diabetic microangiopathy and neuropathy

Basically microscopically your vessels have three layers ,intima ,media and adventitia…High blood sugar causes oxidative damage to the layers and result in their thickening leading to reduced blood supply (ischameia)… ischaemia lead to tissue death as the tissues don’t get O2 and nutrients

Neuropathy is when similar process thicken the myelin sheath covering nerves and the nerve conduction is affected and the patient loses sensation over the limb