As Handsome Jack said, “When you headbutt someone, you gotta aim for the nose bridge.”
Another saying I’ve heard before, “When fighting, hit soft locations with hard body parts, and hard locations with soft body parts.” I.E., Aim a fist at the sternum, neck, nose; throw a palm at the face, a shin at the back of the knee, elbow to the upper spinal cord where the brain stem is housed.
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