You can ask this for a lot of different stuff, and the answer is usually quantity/concentration. Eating an orange is healthy, but juicing 5 of them and drinking it several times a day is not.
Stimulants are in a different category since you are altering your brain chemistry where it needs to recalibrate the feelgood scale from having a 1-10 range to 1-100, and there is now only one thing that can nudge you over 10%.
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