I can understand that you dont have to make physical effort to feel tired, because I work as a computer programmer and I feel tired after making mental effort, but this effort seems way bigger than the one required to drive, yet, after 4,5 hours of driving I feel way more exhausted than after 8,10 hours of coding.
In: Biology
In addition to the mental aspects brought up by other commentors, your body makes tons of corrections to keep yourself sitting upright and centered against the forces of acceleration, braking, and turning. A few minutes of this is nothing, but spread over a period of hours can be draining.
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