My uninitiated mind would think that it would be the other way around.
I was watching a video about nuclear power. The guy being interviewed was wearing safety glasses and nitrile gloves while holding a uranium fuel pellet. Then the camera pans to a screen showing the robot handling spent fuel in the bottom of a 40-foot deep pool of heavy water. The pool is in a room behind a big red door with every “do not enter” warning imaginable. I would think the fuel would be less radioactive coming out than going in.
In: Chemistry
Think of it like this: Before you put something in the oven it is safe to handle, after it spent a bunch of time in a hot oven you can’t pick it up with your bare hands for some time*
*YMMV
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