Assumimg that being overweight is due to fat, not muscle.
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In addition to what I see stated, fat cells in themselves are inflammatory, causing a cascade of chemical responses in the body that make us more prone to many maladies. Interesting research is available on the topic.
It’s just bad for you long term. Adipose tissue (fat) releases adipokines which are far specific cytokines. Cytokines are what your body releases during an inflammatory responses (when you get injured or sick)
So when you carry a lot of excess fat, your body is basically in a state of low grade inflammation constantly, and this state of stress just wears everything out way faster.
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