Why is it that the most addictive substances are also the most dangerous? Shouldn’t those two factors be independent?

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Why is it that the most addictive substances are also the most dangerous? Shouldn’t those two factors be independent?

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Botox is very dangerous and it’s not addictive. It’s just that some of the things that are addictive are also dangerous and it’s easy to overdose if your organism craves more of the addictive stuff. But your body does not crave radium so it’s definitely not addictive – yet, it’s extremely dangerous.

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