Homeostasis involves an absolute tonne of different unique chemical reactions, in order to just increase metabolism outright whilst remaining healthy you’d have to increase the rate of every single one by the perfect amount, which won’t be the same for every reaction.
Thermoregulation would then have to increase accordingly. Organs would have to operate faster, which may not be good for them if they’re not strong enough. Your intake of everything would have to increase as well as your expulsion. Cell division would likely have to increase too to account for more dying as a result of the increased metabolism. The increased energy output has to go somewhere so you’d likely shake if not moving, or overheat.
You’d essentially be overclocking your entire body.
Getting all this right with a drug? Not easy, if not impossible.
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