The human body is an enormously complex chemical reaction robot.
Temperatures affect how fast chemical reactions happen (and similar things like dissolving stuff in water).
If the reaction rates get too far out of whack, the chemistry gets out of whack, and starts to fail at the important job of keeping us alive. We might have too much of this, not enough of that, or a bunch of chemicals might start producing different products that weren’t intended.
While there are other effects, the biggest thing keeping an organism only viable within a small temperature window are the enzymes it uses. Basically put, an enzyme is a protein that reduces the necessary energy required to make a reaction happen
If our enzymes even started finding it slightly harder to do the things they did, we would be dead. If it gets too hot, they may just stop working permanently due to unwanted reactions occurring, and if it gets too cold it won’t have the energy to make the wanted erections happen
TL;DR: important proteins do fucky wucky and throw a hissy fit if it isn’t in perfect conditions
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