Large passenger jets fly above clouds to avoid the weather, and in order to make it comfortable for the crew and passengers, the plane is pressurized.
Maybe not the full 14 psi near sea level, but there is “some” pressure. I also suspect that the atmosphere becomes slightly low in oxygen and high in CO2.
Obviously its not at dangerous levels, but those are the only factors that I think “might” have some effect…I don’t know how, but…it would seem nobody else does either.
Also, flying has a higher risk of worsening macular degeneration (vision). nobody knows why.
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