Disclaimer: not an expert.
Injection tends to be easier on the body overall, because – among other reasons – direct delivery into the bloodstream means a lower dose is sufficient to reach the target concentration of the drug than you’d need with a less efficient delivery method like oral.
But oral has two big advantages. The first one is convenience. It’s just easier to take a pill twice a day than get an injection twice a day (especially if side effects make getting around difficult or if you’re infectious and shouldn’t meet people). The second is retardardation: it’s somewhat easy to basically “program” a pill to give off its drug at a predetermined point/section of your digestive tract (or even have several stages) at a certain rate. Injection, as far as I’m aware, means you get the whole dose of the drug at once, which means drug concentration in your body peaks and then continually goes down, where a pill can give off the drug slowly over a long time, keeping the concentration somewhat stable.
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