why our skin and liver, the largest organs in our body, regenerate but other organs can’t?
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Tissue that gets regenerated regularly (like skin and liver, though skin is MUCH faster) tend to also be tissues that get damaged regularly or are regularly exposed to damaging materials. Organs that don’t do this (brain, heart, etc.) also tend to not get exposed to damaging materials regularly and therefore do not need to regenerate as much. Regeneration takes a large amount of energy and runs risks (increasing chance of cancer is probably the most obvious), so the body is going to evolve to reduce it where possible and increase it where necessary to balance out energy spent vs. risk. It goes deeper than this, i.e. physical constraints, but this may extend beyond an ELI5
Source: Am neuroscience PhD student
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