CO2 adds an acidic taste to the cream. O2 can make it go rancid. Nitrogen is bulky because it can’t be liquified at room temperature (oxygen has the same problem). N2O can be compressed into a liquid, and it’s soluble in fat, so it makes it go a lot creamier than nitrogen or air would. It’s also harmless in small amounts, odorless, tasteless and non-flammable (though it can make flammable stuff burn more fiercely).
Edit: and if it’s abused, it’s probably the drug with the least harmful side effects, milder than both tobacco and alcohol. It’s not without harm however, and long-time abuse can lead to vitamin B12 deficiency, which causes neurological issues. It’s also possible to get frostbite or lung damage when using it wrong, or even death by suffocation if the pure gas is inhaled through a mask, which the incapacitated user is then unable to remove.
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