A nuke wouldnt, although its hard to say the exact consequences when maxing out the nukes, as the biggest nuke testet was deliberately limited.
The issue with nukes is MAD – Mutual Assured Destruction. Essentially, when one nation decides to use a nuke, its a certainty that the nuke will be answered, leading to both nations getting nuked. That might start a chain reaction of nukes being utilized, and is a reason as to why you shouldnt nuke anyone.
EDIT: Oh, do you mean from the historical perspective of considerations when first creating the atom bomb?
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